Downregulation of low‐density lipoprotein receptor class A domain‐containing protein 4 ( Ldlrad4 ) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis-Reference-Cited by-同舟云学术

Downregulation of low‐density lipoprotein receptor class A domain‐containing protein 4 ( Ldlrad4 ) in the liver of rats treated with nongenotoxic hepatocarcinogen to induce transforming growth factor β signaling promoting cell proliferation and suppressing apoptosis in early hepatocarcinogenesis

Published:2020-06-28 Issue:11 Volume:40 Page:1467-1479
ISSN:0260-437X
Container-title:Journal of Applied Toxicology
language:en
Short-container-title:J Appl Toxicol

Author:

Ito Yuko¹²,Nakajima Kota¹²,Masubuchi Yasunori¹²,Kikuchi Satomi¹³,Okano Hiromu¹³,Saito Fumiyo⁴⁵,Akahori Yumi⁴,Jin Meilan⁶,Yoshida Toshinori¹³,Shibutani Makoto¹³⁷^ORCID

Affiliation:

1. Laboratory of Veterinary Pathology Tokyo University of Agriculture and Technology Tokyo Japan

2. Pathogenetic Veterinary Science, United Graduate School of Veterinary Sciences Gifu University Gifu Japan

3. Cooperative Division of Veterinary Sciences, Graduate School of Agriculture Tokyo University of Agriculture and Technology Tokyo Japan

4. Chemicals Evaluation and Research Institute Tokyo Japan

5. Department of Toxicology, Faculty of Veterinary Medicine Okayama University of Science Ehime Japan

6. Laboratory of Veterinary Pathology, College of Animal Science and Technology Veterinary Medicine Southwest University Chongqing China

7. Institute of Global Innovation Research Tokyo University of Agriculture and Technology Tokyo Japan

Funder

Institute of Global Innovation Research, Tokyo University of Agriculture and Technology

Publisher

Wiley

Subject

Toxicology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jat.3998

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5. Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

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