Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma

Author:

Jardin Fabrice1,Pujals Anais2,Pelletier Laura2,Bohers Elodie1,Camus Vincent1,Mareschal Sylvain1,Dubois Sydney1,Sola Brigitte3,Ochmann Marlène4,Lemonnier François2,Viailly Pierre-Julien1,Bertrand Philippe1,Maingonnat Catherine1,Traverse-Glehen Alexandra4,Gaulard Philippe2,Damotte Diane5,Delarue Richard6,Haioun Corinne2,Argueta Christian7,Landesman Yosef7,Salles Gilles8,Jais Jean-Philippe9,Figeac Martin10,Copie-Bergman Christiane2,Molina Thierry Jo11,Picquenot Jean Michel1,Cornic Marie1,Fest Thierry4,Milpied Noel12,Lemasle Emilie1,Stamatoullas Aspasia1,Moeller Peter13,Dyer Martin J.S14,Sundstrom Christer15,Bastard Christian1,Tilly Hervé1,Leroy Karen2

Affiliation:

1. Departement of Hematology; Inserm U918, Centre Henri Becquerel; Rouen France

2. Departement of Hematology; Inserm U955 Team 09, APHP Hospital Henri Mondor; Créteil France

3. Departement of Hematology; Normandie Univ, UNICAEN; Caen EA4652 France

4. Departement of Hematology; Inserm U917, CHU Pontchaillou; Rennes France

5. Departement of Hematology; Hospices Civils De Lyon, Lyon-1 University; Pierre Benite CNRS UMR5239 France

6. Department of Pathology; Hôpitaux Universitaires, Paris Centre, Team « Cancer, Immune Control, and Escape » INSERM U1138, Cordeliers Research Center; Paris France

7. Department of Hematology; Necker Hospital, AP-HP; Paris France

8. Karyopharm Therapeutics; Newton MA

9. Department of Biostatistics; Hopital Necker; Paris France

10. Departement of Genomics; Functional Genomic Platforms, IRCL; Lille France

11. Department of Pathology; Necker Hospital, AP-HP; Paris France

12. Department of Hematology; CHU De Bordeaux France

13. Department of Pathology; Institute of Pathology, University of Ulm; Germany

14. Department of Hematology; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester; United Kingdom

15. Department of Pathology; Uppsala Sweden

Funder

French National Institute of Cancer (INCA)

Cancer Research Association (ARC)

Ligue Regionale Contre le Cancer (Normandie)

Publisher

Wiley

Subject

Hematology

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