Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis-Reference-Cited by-同舟云学术

Does vitamin D supplementation impact serotonin levels? A systematic review and meta‐analysis

Published:2024-07-30 Issue:8 Volume:7 Page:
ISSN:2398-8835
Container-title:Health Science Reports
language:en
Short-container-title:Health Science Reports

Author:

Alimohammadi‐Kamalabadi Malek¹,Ziaei Somayeh²,Hasani Motahareh³,Mohammadi Shooka⁴^ORCID,Mehrbod Milad⁵,Morvaridi Mehrnaz⁶,Persad Emma⁷,Belančić Andrej⁸,Malekahmadi Mahsa⁹,Estêvão Maria Dulce da Mota Antunes de Oliveira¹⁰,Daneshzad Elnaz¹¹,Heshmati Javad¹²^ORCID

Affiliation:

1. Department of Cellular‐Molecular Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran

2. ICU Department, Emam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran

3. Department of Nutritional Sciences, School of Health Golestan University of Medical Sciences Gorgan Iran

4. Department of Social and Preventive Medicine, Faculty of Medicine University of Malaya Kuala Lumpur Malaysia

5. Department of Internal Medicine, Faculty of Medicine Tehran University of Medical Sciences Tehran Iran

6. Department of Nutrition, School of Public Health Iran University of Medical Sciences Tehran Iran

7. Department for Evidence‐based Medicine and Evaluation Danube University Krems Krems Austria

8. Department of Basic and Clinical Pharmacology with Toxicology, Faculty of Medicine University of Rijeka Rijeka Croatia

9. Imam Khomeini Hospital Complex Tehran University of Medicinal Sciences Tehran Iran, Tehran University of Medical Sciences Tehran Iran

10. Universidade do Algarve, Escola Superior de Saúde Campus de Gambelas Faro Portugal

11. Non‐Communicable Diseases Research Center Alborz University of Medical Sciences Karaj Iran

12. University of Ottawa Heart Institute Ottawa Ontario Canada

Abstract

AbstractBackground and AimsVitamin D deficiency impacts a significant proportion of the world's population, and this deficiency has been linked to various conditions characterized by imbalanced serotonin regulation. The objective of this systematic review and meta‐analysis was to evaluate the effect of vitamin D supplementation on serum serotonin levels.MethodsWe conducted a comprehensive search of PubMed, Scopus, Cochrane Central for Randomized Clinical Trials, and Web of Science up to September 2022, without any language restrictions. The effect sizes were calculated using the standard mean difference (SMD) and 95% confidence interval (CI).ResultsSix randomized clinical trials involving 356 participants were included in the analysis. Our findings indicated no significant changes in serotonin levels between the intervention and control groups (SMD: 0.24 ng/mL, 95% CI: −0.28, 0.75, p > 0.10). Subgroup analysis also did not reveal any significant changes in serotonin levels among children, participants with autism spectrum disorders, interventions lasting 10 weeks or longer, or those receiving vitamin D doses below 4000 IU/day.ConclusionAlthough the results obtained in this systematic review are inconclusive, they support the need for further well‐designed randomized trials to assess the potential role of vitamin D supplementation in regulating serotonin levels and potentially ameliorating depression and related disorders.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hsr2.2276

Reference39 articles.

1. Serotonin (5-hydroxytryptamine)-immunoreactive neurons in the brain of the viviparous fish Gambusia affinis

2. The Dual Role of Serotonin in Colorectal Cancer

3. Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers

4. BakshiA TadiP. Biochemistry serotonin. 2020.

5. The Serotonin-Immune Axis in Preeclampsia