Affiliation:
1. Area Brain Aging and Mental Health, Department of Psychiatry Columbia University Irving Medical Center New York New York USA
2. The Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University New York New York USA
3. Center for Cognitive Neurology, Department of Neurology New York University Grossman School of Medicine New York New York USA
4. Departments of Psychiatry and Pathology New York University Grossman School of Medicine New York New York USA
Abstract
AbstractIntroductionMild to moderate exercise may decrease Alzheimer's disease (AD) risk, but the effects of vigorous, regular physical exercise remain unclear.MethodsTwo patients with initial diagnoses of amnestic mild cognitive impairment (MCI) demonstrated positive AD biomarkers throughout 16 and 8 years of follow‐up, with final diagnoses of mild AD and amnestic MCI, respectively.ResultsPatient 1 was diagnosed with amnestic MCI at age 64. Neuropsychological testing, magnetic resonance imaging (MRI), fluorodeoxyglucose–positron emission tomography (FDG‐PET), amyloid imaging PET, and cerebrospinal fluid (CSF) biomarkers during follow‐ups remained consistent with AD. By age 80, progression was minimal with Montreal Cognitive Assessment (MoCA) 26 of 30. Patient 2 was diagnosed with amnestic MCI at age 72. Neuropsychological testing, MRI, FDG‐PET, and amyloid imaging PET during follow‐ups remained consistent with AD. At age 80, MoCA was 27 of 30 with no clinical progression. Both patients regularly performed vigorous, regular exercise that increased after retirement/work reduction.DiscussionVigorous, regular exercise may slow disease progression in biomarker‐positive amnestic MCI and mild AD.
Funder
National Institute on Aging
Alzheimer's Association
Subject
Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology
Cited by
2 articles.
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