Biopsychosocial frailty and mild cognitive impairment subtypes: Findings from the Italian project on the epidemiology of Alzheimer's disease (IPREA)

Author:

Solfrizzi Vincenzo1,Scafato Emanuele2,Custodero Carlo1,Piazzolla Giuseppina1,Capogna Lavinia1,Procaccio Annagrazia1,Gandin Claudia2,Galluzzo Lucia3,Ghirini Silvia2,Matone Alice2,Dibello Vittorio4,Sardone Rodolfo5,Daniele Antonio67,Lozupone Madia8,Panza Francesco5,

Affiliation:

1. “Cesare Frugoni” Internal and Geriatric Medicine and Memory Unit, University of Bari “Aldo Moro” Bari Italy

2. Osservatorio Nazionale Alcol, Centro Nazionale Dipendenze e Doping Istituto Superiore di Sanità Rome Italy

3. Department of Cardiovascular, Endocrine‐Metabolic Diseases, and Aging Istituto Superiore di Sanità (ISS) Rome Italy

4. Department of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands

5. Unit of Research Methodology and Data Sciences for Population Health, National Institute of Gastroenterology “Saverio de Bellis” Research Hospital Bari Italy

6. Department of Neuroscience Catholic University of Sacred Heart Rome Italy

7. Neurology Unit, IRCCS Fondazione Policlinico Universitario A. Gemelli Rome Italy

8. Department of Translational Biomedicine and Neuroscience “DiBrain” University of Bari Aldo Moro Bari Italy

Abstract

AbstractIntroductionFrailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial phenotypes. We operationalized a biopsychosocial frailty construct, estimating its association with mild cognitive impairment (MCI) and its subtypes.MethodsIn 1980, older individuals from the population‐based Italian PRoject on the Epidemiology of Alzheimer's disease (IPREA), we investigated cross‐sectional associations among biopsychosocial frailty, MCI, and its subtypes.ResultsParticipants with biopsychosocial frailty showed an increased odds ratio (OR) of MCI [OR: 4.36; 95% confidence interval (CI): 2.60‐7.29; Fisher's exact p < 0.01], particularly for nonamnestic MCI single domain (naMCI‐SD, OR:3.28; 95% CI: 1.35‐7.97; Fisher's exact p = 0.02) and for nonamnestic MCI multiple domain (naMCI‐MD, OR:6.92; 95% CI: 3.37‐14.21; Fisher's exact p < 0.01). No statistically significant associations between amnestic MCI single or multiple domain and biopsychosocial frailty were observed.DiscussionIn a large, older Italian cohort, a biopsychosocial frailty phenotype was associated with MCI, in particular, could be associated with some of its subtypes, that is, naMCI‐SD, and naMCI‐MD.

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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