Affiliation:
1. Department of Otolaryngology–Head and Neck Surgery Stanford University School of Medicine Stanford California USA
2. Department of Pediatrics–Medical Genetics Stanford University School of Medicine California USA
Abstract
AbstractObjectiveThe objectives of this study were to describe trends in single‐gene GJB2/6 (connexin 26/30) and multigene hearing loss panel (HLP) testing for hereditary hearing loss using real‐world evidence.Study DesignRetrospective study using insurance claims data.SettingOptum Data Mart database from 2015 to 2020.MethodsRates of overall and hearing‐specific genetic testing and costs to insurers and patients were reported. Linear regression models were used to assess the proportion of single‐gene GJB2/6 testing over time. Additional linear regression models were used to assess changes in costs over time.ResultsFrom 2015 to 2020, 91,986 children received genetic testing for any indication, of which 601 (0.65%) received hearing‐specific tests. The proportion of single‐gene GJB2/6 testing remained similar over time (mean difference [MD]: −1.3% per year; 95% confidence interval [CI]: −4.3%, 1.7%), while multigene HLP use increased over time (MD: 4.0% per year; 95% CI: 0.4%, 7.5%). The median charge for single‐gene GJB2/6 testing remained constant during the study period (MD: −$34; 95% CI: −$86, $18), while the median charge for multigene HLP decreased during the study period (MD: −$145 per year; 95% CI: −$278, −$12).ConclusionCompared to molecular testing for GJB2/6, HLPs are becoming more common for hereditary hearing loss. The comprehensiveness of HLP and decreasing costs provide justification for its more widespread adoption moving forward.
Subject
Otorhinolaryngology,Surgery
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献