Ex vivoexpansion of cord blood-CD34+cells using IGFBP2and Angptl-5 impairs short-term lymphoid repopulationin vivo

Author:

Ventura Ferreira Mónica S.1,Labude Norina1,Walenda Gudrun2,Adamzyk Carina1,Wagner Wolfgang2,Piroth Daniela3,Müller Albrecht M.4,Knüchel Ruth1,Hieronymus Thomas25,Zenke Martin25,Jahnen-Dechent Willi6,Neuss Sabine16

Affiliation:

1. Institute of Pathology; RWTH Aachen University; Germany

2. Helmholtz Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering Group; RWTH Aachen University; Germany

3. Department for Gynecology; RWTH Aachen University; Germany

4. Institute for Medical Radiation and Cell Research; University of Würzburg; Germany

5. Institute for Biomedical Engineering, Department of Cell Biology; RWTH Aachen University; Germany

6. Helmholtz Institute for Biomedical Engineering, Biointerface Group; RWTH Aachen University; Germany

Publisher

Wiley

Subject

Biomedical Engineering,Biomaterials,Medicine (miscellaneous)

Reference44 articles.

1. Direct contact with mesenchymal stromal cells affects migratory behavior and gene expression profile of CD133+ hematopoietic stem cells during ex vivo expansion;Alakel;Exp Hematol,2009

2. Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents;Araki;Exp Hematol,2006

3. Insulin-like growth factor binding proteins-2 and −4 enhance the migration of human CD34-/CD133+ hematopoietic stem and progenitor cells;Bartling;Int J Mol Med,2010

4. Umbilical cord blood transplantation and banking;Brunstein;Annu Rev Med,2006

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