Effect of Body Weight on Risk‐Benefit and Dosing Regimen Recommendation of Secukinumab for the Treatment of Moderate to Severe Plaque Psoriasis
Author:
Affiliation:
1. Office of Clinical PharmacologyUS Food and Drug Administration Silver Spring Maryland USA
2. Office of New DrugsUS Food and Drug Administration Silver Spring Maryland USA
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/cpt.1478
Reference9 articles.
1. A Guide to Rational Dosing of Monoclonal Antibodies
2. Fixed Dosing Versus Body Size-Based Dosing of Therapeutic Peptides and Proteins in Adults
3. Impact of weight on the efficacy and safety of ustekinumab in patients with moderate to severe psoriasis: Rationale for dosing recommendations
4. Obesity and psoriasis: body weight and body mass index influence the response to biological treatment
5. FDA.Cosentyx (secukinumab) [product labeling] (2015). Accessed February 26 2019.
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1. Effectiveness and safety of secukinumab updosing in patients with moderate to severe plaque psoriasis: data from the PURE registry;Archives of Dermatological Research;2024-06-08
2. Optimization of secukinumab dose regimens in patients with moderate-to-severe plaque psoriasis via exposure-response modeling;Expert Review of Clinical Pharmacology;2023-09-22
3. CorrespondenceUpdosing of secukinumab to every 2 weeks results in superior efficacy in patients with severe psoriasis weighing 90 kg or more: a real-world prospective observational study;Clinical and Experimental Dermatology;2023-02-09
4. Weighing in on weight‐based secukinumab dosing for psoriasis;British Journal of Dermatology;2022-05-16
5. Secukinumab dosing every 2 weeks demonstrated superior efficacy compared with dosing every 4 weeks in patients with psoriasis weighing 90 kg or more: results of a randomized controlled trial*;British Journal of Dermatology;2022-04-08
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