Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) cohort-Reference-Cited by-同舟云学术

Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) cohort

Published:2023-06-09 Issue:S9 Volume:19 Page:
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Polsinelli Angelina J.¹,Wonderlin Ryan J.²,Hammers Dustin B.¹,Garcia Alex Pena²,Eloyan Ani³,Taurone Alexander³,Thangarajah Maryanne³,Beckett Laurel⁴,Gao Sujuan⁵,Wang Sophia⁶,Kirby Kala¹,Logan Paige E.¹,Aisen Paul⁷,Dage Jeffrey L.¹⁸,Foroud Tatiana⁸,Griffin Percy⁹,Iaccarino Leonardo¹⁰,Kramer Joel H.¹⁰,Koeppe Robert¹¹,Kukull Walter A.¹²,La Joie Renaud¹⁰,Mundada Nidhi S.¹⁰,Murray Melissa E.¹³,Nudelman Kelly⁸,Soleimani‐Meigooni David N.¹⁰,Rumbaugh Malia⁸,Toga Arthur W.¹⁴,Touroutoglou Alexandra¹⁵,Vemuri Prashanthi¹⁶,Atri Alireza¹⁷,Day Gregory S.¹⁸,Duara Ranjan¹⁹,Graff‐Radford Neill R.¹⁸,Honig Lawrence S.²⁰,Jones David T.¹⁶²¹,Masdeu Joseph²²,Mendez Mario F.²³,Womack Kyle²⁴,Musiek Erik²⁴,Onyike Chiadi U.²⁵,Riddle Meghan²⁶,Rogalski Emily²⁷,Salloway Steven²⁶,Sha Sharon J.²⁸,Turner Raymond S.²⁹,Wingo Thomas S.³⁰,Wolk David A.³¹,Carrillo Maria C.⁹,Dickerson Bradford C.¹⁵,Rabinovici Gil D.¹⁰,Apostolova Liana G.⁷³²,

Affiliation:

1. Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA

2. Marian University College of Osteopathic Medicine Indianapolis Indiana USA

3. Department of Biostatistics Center for Statistical Sciences, Brown University Providence Rhode Island USA

4. Department of Public Health Sciences University of California – Davis Davis California USA

5. Department of Biostatistics Indiana University School of Medicine Indianapolis Indiana USA

6. Department of Psychiatry Indiana University School of Medicine Indianapolis Indiana USA

7. Alzheimer's Therapeutic Research Institute University of Southern California San Diego California USA

8. Department of Medical and Molecular Genetics Indiana University School of Medicine Indianapolis Indiana USA

9. Medical & Scientific Relations Division Alzheimer's Association Chicago Illinois USA

10. Department of Neurology University of California – San Francisco San Francisco California USA

11. Department of Radiology University of Michigan Ann Arbor Michigan USA

12. Department of Epidemiology University of Washington Seattle Washington USA

13. Department of Neuroscience Mayo Clinic Jacksonville Florida USA

14. Laboratory of Neuro Imaging USC Stevens Neuroimaging and Informatics Institute Keck School of Medicine of USC Los Angeles California USA

15. Department of Neurology Massachusetts General Hospital and Harvard Medical School Boston Massachusetts USA

16. Department of Radiology Mayo Clinic Rochester Minnesota USA

17. Banner Sun Health Research Institute Sun City Arizona USA

18. Department of Neurology Mayo Clinic Jacksonville Florida USA

19. Wien Center for Alzheimer's Disease and Memory Disorders Mount Sinai Medical Center Miami Florida USA

20. Taub Institute and Department of Neurology Columbia University Irving Medical Center New York New York USA

21. Department of Neurology Mayo Clinic Rochester Minnesota USA

22. Nantz National Alzheimer Center Houston Methodist and Weill Cornell Medicine Houston Texas USA

23. Department of Neurology David Geffen School of Medicine at UCLA Los Angeles California USA

24. Department of Neurology Washington University School of Medicine in St. Louis St. Louis Missouri USA

25. Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine Baltimore Maryland USA

26. Department of Psychiatry Alpert Medical School Brown University Providence Rhode Island USA

27. Department of Psychiatry and Behavioral Sciences Mesulam Center for Cognitive Neurology and Alzheimer's Disease Feinberg School of Medicine Northwestern University Chicago Illinois USA

28. Department of Neurology & Neurological Sciences Stanford University Palo Alto California USA

29. Department of Neurology Georgetown University Washington D.C. USA

30. Department of Neurology and Human Genetics Emory University School of Medicine Atlanta Georgia USA

31. Department of Neurology Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

32. Department of Radiology and Imaging Sciences Center for Neuroimaging Indiana University School of Medicine Indianapolis Indianapolis Indiana USA

Abstract

AbstractIntroductionWe examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early‐onset Alzheimer's disease (EOAD; onset 40‐64 years) at the midway point of data collection for the Longitudinal Early‐onset Alzheimer's Disease Study (LEADS).MethodsBaseline NPS (Neuropsychiatric Inventory – Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups – amyloid‐positive EOAD (n = 212) and amyloid negative early‐onset non‐Alzheimer's disease (EOnonAD; n = 70).ResultsAffective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD.DiscussionOverall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late‐onset AD.

Funder

National Institute on Aging

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

Reference22 articles.

1. Early-Onset Alzheimer Disease

2. Rate of early onset Alzheimer's disease: a systematic review and meta‐analysis;Zhu X‐C;Ann Transl Med,2015

3. Progression of neuropsychiatric symptoms in young-onset versus late-onset Alzheimer’s disease

4. A systematic review of the prevalence of depression, anxiety, and apathy in frontotemporal dementia, atypical and young-onset Alzheimer’s disease, and inherited dementia

5. Research protocol of the NeedYD‐study (Needs in Young onset Dementia): a prospective cohort study on the needs and course of early onset dementia;Vliet D;BMC Geriatrics,2010