Affiliation:
1. Rush Alzheimer's Disease Center Rush University Medical Center Chicago Illinois USA
2. Department of Neurological Sciences Rush University Medical Center Chicago Illinois USA
3. Department of Psychiatry and Behavioral Sciences Rush University Medical Center Chicago Illinois USA
4. Department of Pathology (Neuropathology) Rush University Medical Center Chicago Illinois USA
Abstract
AbstractINTRODUCTIONExamining motor and cognitive decline in separate models may underestimate their associations.METHODSIn a single trivariate model, we examined the levels and rates of decline of three phenotypes, sensor‐derived total daily physical activity, motor abilities, and cognition in 1007 older adults during 6 years of follow‐up. In 477 decedents, we repeated the model adding fixed terms for indices of nine brain pathologies.RESULTSSimultaneous rates of decline of all three phenotypes showed the strongest correlations with shared variance of up to 50%. Brain pathologies explained about 3% of the variance of declining daily physical activity, 9% of declining motor abilities, and 42% of cognitive decline.DISCUSSIONThe rates of declining cognitive and motor phenotypes are strongly correlated and measures of brain pathologies account for only a small minority of their decline. Further work is needed to elucidate the biology underlying correlated cognitive and motor decline in aging adults.
Subject
Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology
Cited by
2 articles.
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