Affiliation:
1. Islamic Azad University Department of Chemical Engineering, Marvdasht Branch Marvdasht Iran
2. University of Kashan Department of Chemical Engineering, Faculty of Engineering 87317-53153 Kashan Iran
3. National Iranian Oil Company South Zagros Oil and Gas Production 7135717991 Shiraz Iran
4. Islamic Azad University Department of Petroleum Engineering, Marvdasht Branch Marvdasht Iran
Abstract
AbstractProper medication dissolution must be ensured when developing or manufacturing a new solid dosage form. Quantitative analyses performed in dissolution or release tests become simpler when applying mathematical formulae which represent dissolution outcomes as a function of several dosage form properties. Methodologies utilized to examine the kinetics of drug release from controlled‐release formulations are reviewed. The analysis of variance was conducted using statistical, model‐independent, and ‐dependent techniques for the dissolution profile comparison and fitting, respectively. Model equations, including zero‐ and first‐order, Hixson‐Crowell, Weibull, Higuchi, Korsmeyer‐Peppas, Baker‐Lonsdale, Hopfenberg, etc., were employed to match the experimental data. Additional release parameters were taken to illustrate the drug release patterns. Using correlation factors and the Akaike information criterion (AIC), the best‐fitting model was discovered, as were the transport phenomena affecting the behavior of the recognized formulations.
Subject
Industrial and Manufacturing Engineering,Filtration and Separation,Process Chemistry and Technology,Biochemistry,Chemical Engineering (miscellaneous),Bioengineering
Cited by
22 articles.
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