Affiliation:
1. School of Radiology The Second Affiliated Hospital of Shandong First Medical University Taian 271000 China
2. Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong 250000 China
3. Department of Clinical Medicine Shandong First Medical University and Shandong Academy of Medical Sciences Tai'an China
4. School of Radiology Shandong First Medical University and Shandong Academy of Medical Sciences Tai'an China
5. Science and Technology Innovation Center Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China
Abstract
The 3D bioprinting can controllably deposit bioink containing cells and fabricate complex bionic tissue structures in a fast and scalable way, which is expected to completely change the scenario of clinical organ transplantation. Bioprinting holds broad application prospect in tissue engineering, life sciences, and clinical medicine. In the process of 3D bioprinting, bioink, as the carrier of cells and bioactive substances, influences cell activity and accuracy of organ structure after printing. To better understand and design bioink, in this review, the concept, development, and basic composition of bioink are introduced, while focusing on the advantages and disadvantages of various biomaterials, and the use of common cells and biomolecules that constitute bioink. In addition, the properties and applications of various stimuli‐responsive smart materials for 4D bioprinting are mentioned. The challenges and development trends of bioink are also summarized.
Subject
Condensed Matter Physics,General Materials Science