Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge

Author:

Tara Sylvia,Elcock Adrian H.,Kirchhoff Paul D.,Briggs James M.,Radic Zoran,Taylor Palmer,McCammon J. Andrew

Publisher

Wiley

Subject

Organic Chemistry,Biomaterials,Biochemistry,General Medicine,Biophysics

Reference19 articles.

1. (1981) Biochemistry, 4th ed., W. H. Freeman, San Francisco, CA, p. 1017.

2. Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands

3. Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

4. & (1991) in Cholinesterases: Structure, Function, Mechanism, Genetics and Cell Biology, Ed. American Chemical Society, Washington, DC.

5. Acetylcholinesterase: Effects of Ionic Strength and Dimerization on the Rate Constants

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