Targeted‐dose of busulfan: Higher risk of sinusoidal obstructive syndrome observed with systemic exposure dose above 5000 µMol⸱min. A historically controlled clinical trial

Author:

Esteves Iracema12ORCID,Santos Fabio Pires Souza1,Ribeiro Andreza Alice Feitosa1,Seber Adriana3,Sugawara Eduardo Kinio4,Sobrinho Jairo José do Nascimento1,Barros José Carlos5,Oliveira José Salvador Rodrigues2,Fernandes Juliana Folloni16,Hamerschlak Nelson1,Andersson Borje S.7,de Lima Marcos8,Kerbauy Fabio Rodrigues2

Affiliation:

1. Hospital Israelita Albert Einstein São Paulo Brazil

2. Universidade Federal de São Paulo (UNIFESP) São Paulo Brazil

3. Hospital Samaritano São Paulo Brazil

4. Associação Fundo de Incentivo à Pesquisa (AFIP) São Paulo Brazil

5. Transplantation Hospital Dr. Euryclides de Jesus Zerbini São Paulo Brazil

6. Bone Marrow Transplantation Unit Itaci Hospital, Faculdade de Medicina da Universidade de São Paulo (FMUSP) São Paulo Brazil

7. Department of Stem Cell Transplantation and Cellular Therapy The University of Texas MD Anderson Cancer Center Houston Texas USA

8. Case Western Reserve University, University Hospitals of Cleveland Cleveland Ohio USA

Funder

Ministério da Saúde

Publisher

Wiley

Subject

Cancer Research,Oncology,Hematology,General Medicine

Reference38 articles.

1. A risk score for mortality after allogeneic hematopoietic cell transplantation;Parimon T;Ann Intern Med,2006

2. Toxic Injury to Hepatic Sinusoids: Sinusoidal Obstruction Syndrome (Veno-Occlusive Disease)

3. Avoiding hepatic veno-occlusive disease: what do we know and where are we going?

4. Risk factors for hepatic veno‐occlusive disease after high‐dose busulfan‐containing regimens followed by autologous bone marrow transplantation: a study in 136 children;Méresse V;Bone Marrow Transplant,1992

5. Pharmacokinetics of busulfan: correlation with veno-occlusive disease in patients undergoing bone marrow transplantation

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