CYP2C19 Genotype-Dependent Pharmacokinetic Drug Interaction Between Voriconazole and Ritonavir-Boosted Atazanavir in Healthy Subjects

Author:

Zhu Li1,Brüggemann Roger J.2,Uy Jonathan3,Colbers Angela2,Hruska Matthew W.1,Chung Ellen4,Sims Karen1,Vakkalagadda Blisse4,Xu Xiaohui5,van Schaik Ron H. N.6,Burger David M.2,Bertz Richard J.4

Affiliation:

1. Exploratory Clinical and Translational Research; Bristol-Myers Squibb; Princeton NJ USA

2. Department of Pharmacy; Radboud University Nijmegen Medical Centre; Nijmegen; the Netherlands and Radboud Institute for Health Sciences (RIHS); Nijmegen the Netherlands

3. Exploratory Clinical and Translational Research; Bristol-Myers Squibb; Plainsboro NJ USA

4. Exploratory Clinical and Translational Research; Bristol-Myers Squibb; Hopewell NJ USA

5. Bioanalytical Sciences; Bristol-Myers Squibb; Princeton NJ USA

6. Department of Clinical Chemistry (AKC); Erasmus University Medical Centre; Rotterdam the Netherlands

Funder

Bristol-Myers Squibb

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference39 articles.

1. Panel on Antiretroviral Guidelines for Adults and Adolescents Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents 2014 http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf

2. Pharmacokinetics and drug-drug interactions of antiretrovirals: an update;Dickinson;Antiviral Res,2010

3. Drug interactions between antiretrovirals and new or emerging direct-acting antivirals in HIV/hepatitis C virus coinfection;Karageorgopoulos;Curr Opin Infect Dis,2014

4. Management of tuberculosis in HIV-infected patients;Curran;AIDS Rev,2012

5. Clinically relevant drug-drug interactions between antiretrovirals and antifungals;Vadlapatla;Expert Opin Drug Metab Toxicol,2014

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