Affiliation:
1. Department of Neurology University of Michigan Ann Arbor Michigan USA
2. Department of Psychiatry University of Michigan Ann Arbor Michigan USA
3. Department of Radiology Mayo Clinic Rochester Minnesota USA
4. Peninsula Clinical School Monash University Melbourne Victoria Australia
5. Chronic Kidney Disease Section National Institute of Diabetes and Digestive and Kidney Diseases Phoenix Arizona USA
6. Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes University of Michigan Ann Arbor Michigan USA
Abstract
AbstractWe performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).
Funder
National Institute of Diabetes and Digestive and Kidney Diseases
National Institute on Aging
Subject
Neurology (clinical),General Neuroscience
Cited by
1 articles.
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