Surprising and Highly Efficient Use of Methylmagnesium Chloride as a Non-Nucleophilic Base in the Deprotonation and Alkylation of sp3 Centres Adjacent to Nitriles
Author:
Affiliation:
1. SMACT, School of Chemistry; National University of Ireland Galway; University Road Galway Ireland
2. Roche Ireland Ltd.; Clarecastle Co Clare Ireland
Funder
Irish Research Council for Science, Engineering and Technology
Publisher
Wiley
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201801462/fullpdf
Reference38 articles.
1. Enantioselective Biotransformations of Nitriles in Organic Synthesis
2. Preparation of Nitriles from Halides and Sodium Cyanide. An Advantageous Nucleophilic Displacement in Dimethyl Sulfoxide1a
3. A Poly(ethylene glycol)-Supported Quaternary Ammonium Salt: An Efficient, Recoverable, and Recyclable Phase-Transfer Catalyst
4. Iron-Catalyzed Dehydration of Aldoximes to Nitriles Requiring Neither Other Reagents Nor Nitrile Media
5. Total synthesis of tetronomycin
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3. Non-nucleophilic Grignard Synthesis of Bridged Pyridine–Oxazoline Ligands and Evaluation in Palladium-Catalysed Allylic Alkylation;Synlett;2023-04-25
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