Fluorine at the C5 Position of 2′-Deoxyuridine Enhances Repair of a O 4 -Methyl Adduct by O 6 -Alkylguanine DNA Alkyltransferases
Author:
Affiliation:
1. Department of Chemistry and Biochemistry and Centre for Structural and Functional Genomics; Concordia University; 7141 Sherbrooke St. West H4B 1R6 Montréal Québec Canada
Funder
Natural Sciences and Engineering Research Council of Canada (CA)
Canada Research Chairs
Publisher
Wiley
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Reference35 articles.
1. Reaction products from N-methyl-N-nitrosourea and deoxyribonucleic acid containing thymidine residues. Synthesis and identification of a new methylation product, O4-methyl-thymidine
2. O6-Alkylguanine-DNA Alkyltransferase-Mediated Repair ofO4-Alkylated 2′-Deoxyuridines
3. Multifaceted Roles of Alkyltransferase and Related Proteins in DNA Repair, DNA Damage, Resistance to Chemotherapy, and Research Tools
4. Site-specifically modified oligodeoxynucleotides as probes for the structural and biological effects of DNA-damaging agents
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1. Influence of C5‐Substituents on Repair of O 4 ‐Methyl Adducts of Pyrimidines by O 6 ‐Alkylguanine DNA Alkyltransferases;ChemistrySelect;2020-12-17
2. O4-Alkylated-2-Deoxyuridine Repair byO6-Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification;ChemBioChem;2018-02-12
3. Synthesis and biological applications of fluoro-modified nucleic acids;Organic & Biomolecular Chemistry;2017
4. Structural basis of interstrand cross-link repair by O6-alkylguanine DNA alkyltransferase;Organic & Biomolecular Chemistry;2017
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