Direct Synthesis of Cyanopyrrolidinyl β-Amino Alcohols for the Development of Diabetes Therapeutics
Author:
Affiliation:
1. Department of Chemistry and Biochemistry; Rowan University; 201 Mullica Hill Rd. 08028 Glassboro NJ USA
2. Medical College; California Northstate University; 9700 West Taron Dr 97575 Elk Grove CA USA
Funder
American Chemical Society Petroleum Research Fund
Publisher
Wiley
Subject
Organic Chemistry,Physical and Theoretical Chemistry
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5. Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (Sa)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778)
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