Continuous Platinum-Mediated Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA: The Combined Challenges of Selectivity and Catalyst Deactivation-Reference-Cited by-同舟云学术

Continuous Platinum-Mediated Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA: The Combined Challenges of Selectivity and Catalyst Deactivation

Published:2017-07-18 Issue:27 Volume:2017 Page:3921-3928
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur. J. Org. Chem.

Author:

Baramov Todor¹²,Hassfeld Jorma¹,Gottfried Michael³,Bauer Hermann³,Herrmann Tanja³,Ben Said Mourad³,Roggan Stefan¹^ORCID

Affiliation:

1. Pharmaceuticals; Bayer AG; 42096 Wuppertal Germany

2. Leibniz-Institut für Katalyse e.V. (LIKAT); Albert-Einstein-Str. 29a 18059 Rostock Germany

3. Engineering & Technology; Bayer AG; 51368 Leverkusen Germany

Funder

Innovative Medicines Initiative (IMI)

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.201700625/fullpdf

Reference42 articles.

1. Multiphase reactors – revisited

2. Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products

3. On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

4. Microreactor Technology: A Revolution for the Fine Chemical and Pharmaceutical Industries?

5. Continuous-Flow Chemistry in the Research Laboratory

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