Effects of spironolactone on serum markers of fibrosis in people at high risk of developing heart failure: rationale, design and baseline characteristics of a proof‐of‐concept, randomised, precision‐medicine, prevention trial. The Heart OMics in AGing (HOMAGE) trial

Author:

Pellicori Pierpaolo1,Ferreira João Pedro2,Mariottoni Beatrice3,Brunner‐La Rocca Hans‐Peter4,Ahmed Fozia Z.5,Verdonschot Job4,Collier Tim6,Cuthbert Joe J.7,Petutschnigg Johannes89,Mujaj Blerim10,Girerd Nicolas2,González Arantxa1112,Clark Andrew L.7,Cosmi Franco3,Staessen Jan A.10,Heymans Stephane41314,Latini Roberto15,Rossignol Patrick2,Zannad Faiez2,Cleland John G.F.1

Affiliation:

1. Robertson Institute of Biostatistics and Clinical Trials Unit University of Glasgow Glasgow UK

2. Université de Lorraine, INSERM, Centre d'Investigations Cliniques Plurithématique, INSERM 1433, CHRU de Nancy,Institut Lorrain du Coeur et des Vaisseaux, FCRIN INI‐CRCT Nancy France

3. Department of Cardiology Cortona Hospital Arezzo Italy

4. Department of Cardiology Maastricht University Medical Center Maastricht The Netherlands

5. Manchester Heart Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Sciences Centre Manchester UK

6. Department of Medical Statistics London School of Hygiene and Tropical Medicine London UK

7. Department of Academic Cardiology Castle Hill Hospital, Hull York Medical School (at University of Hull) Kingston upon Hull UK

8. Department of Cardiology Charité Universitätsmedizin Berlin Berlin Germany

9. DZHK (German Center of Cardiovascular Research), Partner Site Berlin Berlin Germany

10. Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, KU Leuven Department of Cardiovascular Sciences, University of Leuven Leuven Belgium

11. Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA Pamplona Spain

12. CIBERCV, Carlos III Institute of Health Madrid Spain

13. Department of Cardiovascular Sciences Centre for Molecular and Vascular Biology, KU Leuven Leuven Belgium

14. The Netherlands Heart Institute Utrecht The Netherlands

15. Department of Cardiovascular Medicine Istituto di Ricerche Farmacologiche Mario Negri, IRCCS Milan Italy

Funder

Agence Nationale de la Recherche

Publisher

Wiley

Subject

Cardiology and Cardiovascular Medicine

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