Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases-Reference-Cited by-同舟云学术

Perivascular spaces, plasma GFAP, and speeded executive function in neurodegenerative diseases

Published:2024-07-04 Issue:8 Volume:20 Page:5800-5808
ISSN:1552-5260
Container-title:Alzheimer's & Dementia
language:en
Short-container-title:Alzheimer's & Dementia

Author:

Andriuta Daniela¹²³^ORCID,Ottoy Julie³,Ruthirakuhan Myuri³,Feliciano Ginelle³,Dilliott Allison A.⁴,Hegele Robert A.⁵,Gao Fuqiang³,McLaughlin Paula M.⁶,Rabin Jennifer S.³⁷⁸⁹,Wood Alexander Madeline³⁸,Scott Christopher J. M.³,Yhap Vanessa³,Berezuk Courtney³,Ozzoude Miracle³,Swardfager Walter³,Zebarth Julia³,Tartaglia M. Carmela¹⁰,Rogaeva Ekaterina¹¹,Tang‐Wai David F.¹⁰,Casaubon Leanne¹⁰,Kumar Sanjeev¹²,Dowlatshahi Dar¹³,Mandzia Jennifer⁵,Sahlas Demetrios¹⁴,Saposnik Gustavo¹⁵,Fischer Corinne E.¹⁵¹⁶,Borrie Michael⁵,Hassan Ayman¹⁴¹⁷,Binns Malcolm A.¹⁸¹⁹,Freedman Morris¹⁸,Chertkow Howard⁹¹⁸,Finger Elizabeth⁵,Frank Andrew¹³²⁰,Bartha Robert⁵,Symons Sean²¹,Zetterberg Henrik²²²³²⁴,Swartz Richard H.³⁹²⁵,Masellis Mario³⁹²⁵,Black Sandra E.³⁹²⁵,Ramirez Joel³²⁶,

Affiliation:

1. Department of Neurology Amiens University Medical Center Amiens France

2. Laboratoire de Neurosciences Fonctionnelles et Pathologies (UR UPJV 4559) Jules Verne University of Picardy Amiens France

3. Dr. Sandra Black Centre for Brain Resilience and Recovery LC Campbell Cognitive Neurology, Hurvitz Brain Sciences Program, Sunnybrook Research Institute Toronto Ontario Canada

4. Department of Neurology and Neurosurgery Montreal Neurological Institute and Hospital, McGill University Montréal Quebec Canada

5. Robarts Research Institute Schulich School of Medicine and Dentistry Western University, London Toronto Ontario Canada

6. Nova Scotia Health Halifax Nova Scotia Canada

7. Harquail Centre for Neuromodulation Sunnybrook Research Institute Toronto Ontario Canada

8. Rehabilitation Sciences Institute University of Toronto Toronto Ontario Canada

9. Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada

10. Division of Neurology Toronto Western Hospital, University Health Network, University of Toronto Toronto Ontario Canada

11. Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada

12. Department of Psychiatry Adult Neurodevelopment and Geriatric Psychiatry, Centre for Addiction and Mental Health Toronto Ontario Canada

13. University of Ottawa Brain and Mind Research Institute and Ottawa Hospital Research Institute Ottawa Ontario Canada

14. Division of Neurology Department of Medicine Hamilton Health Sciences, McMaster University Hamilton Ontario Canada

15. Li Ka Shing Knowledge Institute, and Division of Neurology Department of Medicine St. Michael's Hospital, University of Toronto Toronto Ontario Canada

16. Keenan Research Centre for Biomedical Science St. Michael's Hospital, University of Toronto Toronto Ontario Canada

17. Thunder Bay Regional Health Research Institute Thunder Bay Ontario Canada

18. Rotman Research Institute, Baycrest Health Sciences Toronto Ontario Canada

19. Division of Biostatistics Dalla Lana School of Public Health Toronto Ontario Canada

20. Bruyère Research Institute Ottawa Ontario Canada

21. Department of Medical Imaging Sunnybrook Health Sciences Centre Toronto Ontario Canada

22. Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden

23. Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden

24. Department of Neurodegenerative Disease UCL Institute of Neurology, Queen Square, UK Dementia Research Institute at UCL London UK

25. Department of Medicine Neurology Sunnybrook Health Sciences Centre Toronto Ontario Canada

26. Graduate Department of Psychological Clinical Science University of Toronto Scarborough Toronto Ontario Canada

Abstract

AbstractINTRODUCTIONWe investigated the effect of perivascular spaces (PVS) volume on speeded executive function (sEF), as mediated by white matter hyperintensities (WMH) volume and plasma glial fibrillary acidic protein (GFAP) in neurodegenerative diseases.METHODSA mediation analysis was performed to assess the relationship between neuroimaging markers and plasma biomarkers on sEF in 333 participants clinically diagnosed with Alzheimer's disease/mild cognitive impairment, frontotemporal dementia, or cerebrovascular disease from the Ontario Neurodegenerative Disease Research Initiative.RESULTSPVS was significantly associated with sEF (c = ‐0.125 ± 0.054, 95% bootstrap confidence interval [CI] [‐0.2309, ‐0.0189], p = 0.021). This effect was mediated by both GFAP and WMH.DISCUSSIONIn this unique clinical cohort of neurodegenerative diseases, we demonstrated that the effect of PVS on sEF was mediated by the presence of elevated plasma GFAP and white matter disease. These findings highlight the potential utility of imaging and plasma biomarkers in the current landscape of therapeutics targeting dementia.Highlights

Perivascular spaces (PVS) and white matter hyperintensities (WMH) are imaging markers of small vessel disease.

Plasma glial fibrillary protein acidic protein (GFAP) is a biomarker of astroglial injury.

PVS, WMH, and GFAP are relevant in executive dysfunction from neurodegeneration.

PVS's effect on executive function was mediated by GFAP and white matter disease.

Funder

Linda C. Campbell Foundation

Vetenskapsrådet

Alzheimer's Association

BrightFocus Foundation

Centre for Addiction and Mental Health

Publisher

Wiley

Reference50 articles.

1. Why Are Perivascular Spaces Important?

2. White Matter Perivascular Spaces on Magnetic Resonance Imaging