High-dose plasmid-mediated VEGF gene transfer is safe in patients with severe ischemic heart disease (Genesis-I). A phase I, open-label, two-year follow-up trial
Author:
Affiliation:
1. Favaloro Foundation University Hospital; Buenos Aires Argentina
2. Department of Physiology; Favaloro University; Buenos Aires Argentina
3. Bio Sidus; Buenos Aires Argentina
Publisher
Wiley
Subject
Cardiology and Cardiovascular Medicine,Radiology, Nuclear Medicine and imaging,General Medicine
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/ccd.24555/fullpdf
Reference24 articles.
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2. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia;Losordo;Circulation,2002
3. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris: A randomized double-blind placebo-controlled study: The Euroinject One trial;Kastrup;J Am Coll Cardiol,2005
4. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: Results of the NORTHERN trial;Stewart;Mol Ther,2009
5. Arteriogenesis induced by intramyocardial vascular endothelial growth factor 165 gene transfer in chronically ischemic pigs;Crottogini;Human Gene Ther,2003
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