Quick response‐encoded chip engraved onto multifunctional aspirin loaded enteric films by fused filament fabrication‐3D printing

Abstract

AbstractDigital fabrication technology revolutionizing the pharmaceutical industry, offering patient‐centric personalized medicine with tailored pharmacotherapy. In this study, we demonstrated fused filament fabrication coupled with hot melt extrusion for the fabrication of aspirin (ASP) loaded enteric film engraved onto QR‐encoded polylactic acid films for enteric intestinal specific ASP delivery. Further, QR‐encoded films (QRFs) were formulated and its physicochemical properties were assessed systematically. All the QRFs were scannable and readable. Interestingly, due to the advantage of the plasticizing effect of ASP, the formulation was optimized with drug and polymer ratio excluding the usage of any filler and plasticizers. The compatibility study was assessed by attenuated total reflectance and Raman spectroscopy. The physicochemical evaluation was further performed by scanning electron microscopy, x‐ray diffraction, differential scanning calorimetry, and thermogravimetric analysis. Gastric resistance was assessed via performing dissolution study at gastric pH for 4 h, with a lag phase followed by radical increase in an alkaline for next 8 h. Korsmeyer–Peppas model was found to be the best‐fit mathematical kinetic model (R2 > 0.9475 and n = 0.514). This type of QRFs can help the tailoring doses and patients can know the details of the drug that has to be taken.