Teaching biologics design using molecular modeling and simulations

Author:

Phillips Andrew1,Srinivas Anusha1,Prentoska Ilina1,O'Dea Margaret1,Kustrup Matthew1,Hurley Sarah1,Bruno Savannah1,Nguyen Vy1,Lai Pin‐Kuang1ORCID

Affiliation:

1. Department of Chemical Engineering and Materials Science Stevens Institute of Technology Hoboken New Jersey USA

Abstract

AbstractTeaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing proper formulations to stabilize mAbs, such as preventing aggregation and mitigating viscosity. Molecular modeling and simulations can improve pharmaceutical products by examining the interactions between mAbs and other compounds, such as excipients. To introduce students to biopharmaceuticals, eight students at the Stevens Institute of Technology participated in a semester‐long course to learn the challenges of pharmaceutical development and different computational skills to study biologics design. The students started with a limited background in this field. Throughout one semester, they were introduced to various literature and software tools for modeling antibodies and studying their interactions with excipients. This paper aims to develop a course structure to be replicated at other universities and institutions to teach biopharmaceutical development to students.

Publisher

Wiley

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