An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2EDTA plasma-Reference-Cited by-同舟云学术

An LC-MS/MS assay for the quantitative determination of 2-pyridyl acetic acid, a major metabolite and key surrogate for betahistine, using low-volume human K2EDTA plasma

Published:2016-08-10 Issue:2 Volume:31 Page:e3790
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomed. Chromatogr.

Author:

Soni Krunal¹,Bhatt Chandrakant¹,Singh Kanchan¹,Bhuvaneshwari P.C.¹,Jha Anil¹,Patel Palak¹,Patel Harilal¹,Srinivas Nuggehally R.¹

Affiliation:

1. Zydus Research Centre; Bioanalytical Laboratory; Ahmedabad India

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bmc.3790/fullpdf

Reference13 articles.

1. Determination of the major metabolite of betahistine (2-pyridyl acetic acid) in human plasma by high performance liquid chromatography-tandem mass spectrometry;Abu Nameh;Journal of Analytical Chemistry,2015

2. Actions of betahistine at histamine receptors in the brain

3. Management of acute vertigo with betahistine;Bradoo;Indian Journal of Otolaryngology, Head and Neck Surgery,2000

4. LC-MS-MS analysis of 2-pyridylacetic acid, a major metabolite of betahistine: application to a pharmacokinetic study in healthy volunteers;Chen;Xenobiotica,2003

5. Betahistine in the treatment of vertiginous syndromes: a meta-analysis;Della Pepa;Acta Otorhinolaryngologica Italica,2006

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1. Eco-Friendly and Sensitive HPLC and TLC Methods Validated for the Determination of Betahistine in the Presence of Its Process-Related Impurity;Separations;2022-02-10