Simultaneous quantification and pharmacokinetic evaluation of roflumilast and its N‐oxide in cynomolgus monkey plasma by LC

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Simultaneous quantification and pharmacokinetic evaluation of roflumilast and its N‐oxide in cynomolgus monkey plasma by LC–MS/MS method

Published:2020-09-07 Issue:2 Volume:35 Page:
ISSN:0269-3879
Container-title:Biomedical Chromatography
language:en
Short-container-title:Biomedical Chromatography

Author:

Qu Haijun¹,Zhang Keyu²,Fu Chunqing²,Qiu Feng²^ORCID

Affiliation:

1. Department of Pharmacy The Affiliated Hospital of Qingdao University Qingdao China

2. Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine Capital Medical University Beijing China

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/bmc.4973

Reference40 articles.

1. Roflumilast, a phosphodiesterase 4 inhibitor, attenuates cadmium-induced renal toxicity via modulation of NF-κB activation and induction of NQO1 in rats

2. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

3. Dose-Proportional Intraindividual Single- and Repeated-Dose Pharmacokinetics of Roflumilast, an Oral, Once-Daily Phosphodiesterase 4 Inhibitor

4. Phosphodiesterase inhibitors

5. In vivo efficacy in airway disease models of roflumilast, a novel orally active PDE4 inhibitor;Bundschuh D. S.;Journal of Pharmacology Experimental Therapeutics,2001

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