Postoperative inflammatory markers predict survival in patients after McKeown esophagectomy for esophageal cancer

Abstract

AbstractBackgroundPreoperative C‐reactive protein‐to‐albumin ratio (CAR) and neutrophil‐to‐lymphocyte ratio (NLR) are correlated with a poor prognosis of various cancers. The significance of postoperative systemic inflammation markers for prognostic stratification of patients with esophageal cancer (EC) has not been established. Therefore, this study aimed to elucidate the impact of postoperative CAR and NLR on survival in patients with EC for prognostic stratification.MethodsA total of 235 patients who received curative esophagectomy were analyzed. A Cox proportional hazard model was performed to detect prognostic factors.ResultsMultivariate analysis revealed that postoperative CAR ≥ 0.05 (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.01–2.57) and NLR ≥ 3.0 (HR, 2.81; 95% CI, 1.79–4.40) were independent prognostic factors for overall survival. Meanwhile, postoperative CAR ≥ 0.05 (HR, 1.61; 95% CI, 1.07–2.41) and NLR ≥ 3.0 (HR, 1.92; 95% CI, 1.29–2.85) were also significant prognostic factors for relapse‐free survival. In addition, the patient group with postoperative CAR ≥ 0.05 and NLR ≥ 3.0 had the worst survival.ConclusionsPostoperative CAR ≥ 0.05 and NLR ≥ 3.0 can predict the poor survival of patients who received curative esophagectomy for EC.