Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis

Author:

Hemdan Nasr Y. A.1,Weigel Cynthia12,Reimann Christina-Maria1,Gräler Markus H.1

Affiliation:

1. Department of Anesthesiology and Intensive Care Medicine; Center for Sepsis Control and Care (CSCC); and the Center for Molecular Biomedicine (CMB); University Hospital Jena; Jena Germany

2. Fritz Lipmann Institute; Leibniz Institute on Aging; Jena Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference38 articles.

1. Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit;Vincent;Lancet. Respir. Med.,2014

2. Characteristics of clinical sepsis reflected in a reliable and reproducible rodent sepsis model;Gonnert;J. Surg. Res.,2011

3. The pathogenesis of sepsis;Stearns-Kurosawa;Annu. Rev Pathol.,2011

4. Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice;Camerer;J. Clin. Invest,2009

5. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement;Garcia;J. Clin. Invest,2001

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