IL-10 production in murine IgM+CD138hicells is driven by Blimp-1 and downregulated in class-switched cells

Author:

Suzuki-Yamazaki Nao1,Yanobu-Takanashi Rieko2,Okamura Tadashi23,Takaki Satoshi1

Affiliation:

1. Department of Immune Regulation; Research Center for Hepatitis and Immunology; Research Institute; National Center for Global Health and Medicine; Ichikawa Chiba Japan

2. Department of Laboratory Animal Medicine; Research Institute; National Center for Global Health and Medicine; Shinjuku Tokyo Japan

3. Section of Animal Models; Department of Infectious Diseases; Research Institute; National Center for Global Health and Medicine; Shinjuku Tokyo Japan

Funder

Japan Society for the Promotion of Science

The Grants for National Center for Global Health and Medicine

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference39 articles.

1. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses;Yanaba;Immunity,2008

2. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression;Matsushita;J. Clin. Invest.,2008

3. B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer;DiLillo;Ann. N. Y. Acad. Sci.,2010

4. Novel suppressive function of transitional 2 B cells in experimental arthritis;Evans;J. Immunol.,2007

5. B cells regulate autoimmunity by provision of IL-10;Fillatreau;Nat. Immunol.,2002

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