Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth

Author:

Miele Evelina1ORCID,Po Agnese2ORCID,Mastronuzzi Angela1ORCID,Carai Andrea3ORCID,Besharat Zein Mersini4ORCID,Pediconi Natalia5,Abballe Luana4,Catanzaro Giuseppina4ORCID,Sabato Claudia4ORCID,De Smaele Enrico4ORCID,Canettieri Gianluca2ORCID,Di Marcotullio Lucia2ORCID,Vacca Alessandra4ORCID,Mai Antonello6ORCID,Levrero Massimo78ORCID,Pfister Stefan M.91011ORCID,Kool Marcel911ORCID,Giangaspero Felice1213ORCID,Locatelli Franco114ORCID,Ferretti Elisabetta4ORCID

Affiliation:

1. Department of Pediatric Hematology and Oncology, Cell and Gene Therapy Bambino Gesù Children's Hospital, IRCCS Rome Italy

2. Department of Molecular Medicine Sapienza University Rome Italy

3. Neurosurgery Unit, Department of Neurological and Psychiatric Sciences Bambino Gesù Children's Hospital, IRCCS Rome Italy

4. Department of Experimental Medicine Sapienza University Rome Italy

5. Center for Life NanoScience@Sapienza Istituto Italiano di Tecnologia Rome Italy

6. Department of Chemistry and Technologies of Drugs Sapienza University of Rome Italy

7. Cancer Research Center of Lyon (CRCL), UMR Inserm 1052 CNRS 5286 Mixte CLB Université de Lyon 1 (UCBL1) France

8. Department of Internal Medicine and Medical Specialties Sapienza University Rome Italy

9. Division of Pediatric Neurooncology German Cancer Research Center DKFZ Heidelberg Germany

10. Department of Pediatric Oncology, Hematology and Immunology University Hospital Heidelberg Germany

11. Hopp Children's Cancer Center Heidelberg (KiTZ) Heidelberg Germany

12. Department of Radiological, Oncological and Pathological Science Sapienza University Rome Italy

13. IRCCS Neuromed Pozzilli Italy

14. Department of Maternal Infantile and Urological Sciences Sapienza University Rome Italy

Funder

Sapienza Università di Roma

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

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