Cannabidiol‐induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET

Author:

Buchtova Tereza1ORCID,Skrott Zdenek1,Chroma Katarina1,Rehulka Jiri1,Dzubak Petr1,Hajduch Marian1,Lukac David1,Arampatzis Stefanos2,Bartek Jiri123ORCID,Mistrik Martin1ORCID

Affiliation:

1. Faculty of Medicine and Dentistry Institute of Molecular and Translational Medicine Palacky University Olomouc Czech Republic

2. Danish Cancer Society Research Center Copenhagen Denmark

3. Division of Genome Biology Department of Medical Biochemistry and Biophysics Science for Life Laboratory Karolinska Institute Stockholm Sweden

Funder

Ministry of Education, Youth and Science

European Regional Development Fund

Novo Nordisk Fonden

Vetenskapsrådet

Cancerfonden

Danmarks Grundforskningsfond

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Reference42 articles.

1. Disulfiram inhibits activating transcription factor/cyclic AMP‐responsive element binding protein and human melanoma growth in a metal‐dependent manner in␣vitro, in mice and in a patient with metastatic disease;Brar SS;Mol Cancer Ther,2004

2. Disulfiram, a Clinically Used Anti-Alcoholism Drug and Copper-Binding Agent, Induces Apoptotic Cell Death in Breast Cancer Cultures and Xenografts via Inhibition of the Proteasome Activity

3. Sodium ditiocarb as adjuvant immunotherapy for high risk breast cancer: A randomized study

4. Evidence for the efficacy of disulfiram and copper combination in glioblastoma multiforme ‐ A propos of a case;Karamanakos PN;J BUON,2017

5. Spontaneous regression of breast cancer;Lewison EF;Natl Cancer Inst Monogr,1976

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