A drug‐repositioning screen for primary pancreatic ductal adenocarcinoma cells identifies 6‐thioguanine as an effective therapeutic agent for TPMT‐low cancer cells

Author:

Kim Inki12,Choi Yeon‐Sook3,Song Jae Hwi3,Choi Eun A3,Park Sojung1,Lee Eun Ji3,Rhee Je‐Keun4,Kim Song Cheol5,Chang Suhwan36

Affiliation:

1. Convergence Medicine Research Center (CREDIT)/Biomedical Research Center Asan Institute for Life Sciences Seoul Korea

2. Department of Convergence Medicine Asan Medical Center University of Ulsan College of Medicine Seoul Korea

3. Department of Biomedical Sciences Asan Medical Center University of Ulsan College of Medicine Seoul Korea

4. Cancer Research Institute Catholic University of Korea Seoul Korea

5. Department of Surgery Asan Medical Center University of Ulsan College of Medicine Seoul Korea

6. Department of Physiology Asan Medical Center University of Ulsan College of Medicine Seoul Korea

Funder

Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea

Asan Institute for Life Sciences

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Reference39 articles.

1. Phase II study of intravenous 6‐thioguanine in patients with advanced carcinoma of the pancreas;Ajani JA;Invest New Drugs,1991

2. Real-time PCR-based assay to quantify the relative amount of human and mouse tissue present in tumor xenografts

3. A response of Panc‐1 cells to cis‐platinum, assessed with a cDNA array;Anderson KM;Anticancer Res,2002

4. Targeting stroma in pancreatic cancer: Promises and failures of targeted therapies

5. Ritonavir-Mediated Induction of Apoptosis in Pancreatic Cancer Occurs via the RB/E2F-1 and AKT Pathways

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