Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells-Reference-Cited by-同舟云学术

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells

Published:2019-10-21 Issue:11 Volume:13 Page:2422-2440
ISSN:1574-7891
Container-title:Molecular Oncology
language:en
Short-container-title:Mol Oncol

Author:

Schoonen Pepijn M.¹,Kok Yannick P.¹,Wierenga Elles¹,Bakker Bjorn²,Foijer Floris²,Spierings Diana C. J.²,Vugt Marcel A. T. M.¹^ORCID

Affiliation:

1. Department of Medical Oncology University Medical Center Groningen University of Groningen The Netherlands

2. European Institute for the Biology of Ageing (ERIBA) University Medical Center Groningen University of Groningen The Netherlands

Funder

KWF Kankerbestrijding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

H2020 European Research Council

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/1878-0261.12573

Reference66 articles.

1. cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

2. Simultaneous inhibition of ATR and PARP sensitizes colon cancer cell lines to irinotecan

3. Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

4. Chromosomal instability drives metastasis through a cytosolic DNA response

5. Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies

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