Dual inhibition of Akt and c-Met as a second-line therapy following acquired resistance to sorafenib in hepatocellular carcinoma cells

Author:

Han Peng1,Li Hali1,Jiang Xian1,Zhai Bo12,Tan Gang2,Zhao Dali1,Qiao Haiquan1,Liu Bing1,Jiang Hongchi1,Sun Xueying1

Affiliation:

1. The Hepatosplenic Surgery Center; Department of General Surgery; the First Affiliated Hospital of Harbin Medical University; China

2. Department of General Surgery; the Fourth Affiliated Hospital of Harbin Medical University; China

Funder

National Natural Scientific Foundation of China

China Postdoctoral Science Foundation

Scientific Fund for Youths

Postdoctoral Science Foundation

Natural Scientific Foundation

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Reference51 articles.

1. Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance;Aksamitiene;Biochem Soc Trans,2012

2. Targeted agents and systemic therapy in hepatocellular carcinoma. Recent results in cancer research. Fortschritte der Krebsforschung;Ang;Progres dans les recherches sur le cancer,2013

3. Hepatocellular carcinoma and sorafenib: too many resistance mechanisms?;Berasain;Gut,2013

4. Targeting the hepatocyte growth factor-cMET axis in cancer therapy;Blumenschein;J Clin Oncol,2012

5. Evidence-based diagnosis, staging, and treatment of patients with hepatocellular carcinoma;Bruix;Gastroenterology,2016

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