Epigenetic priming in chronic liver disease impacts the transcriptional and genetic landscapes of hepatocellular carcinoma

Author:

Gallon John1ORCID,Coto‐Llerena Mairene12ORCID,Ercan Caner2ORCID,Bianco Gaia1,Paradiso Viola2,Nuciforo Sandro3ORCID,Taha‐Melitz Stephanie14,Meier Marie‐Anne3,Boldanova Tujana34,Pérez‐del‐Pulgar Sofía5ORCID,Rodríguez‐Tajes Sergio5ORCID,Flüe Markus4,Soysal Savas D.4ORCID,Kollmar Otto4,Llovet Josep M.67ORCID,Villanueva Augusto7ORCID,Terracciano Luigi M.89ORCID,Heim Markus H.34,Ng Charlotte K. Y.1011ORCID,Piscuoglio Salvatore12ORCID

Affiliation:

1. Visceral Surgery and Precision Medicine Research Laboratory Department of Biomedicine University of Basel Switzerland

2. Institute of Medical Genetics and Pathology University Hospital Basel Switzerland

3. Hepatology Laboratory Department of Biomedicine University of Basel Switzerland

4. Clarunis Department of Visceral Surgery University Centre for Gastrointestinal and Liver Diseases St. Clara Hospital and University Hospital Basel Switzerland

5. Liver Unit Hospital Clinic IDIBAPS CIBERehd University of Barcelona Spain

6. Translational Research in Hepatic Oncology Liver Unit IDIBAPS Hospital Clínic University of Barcelona Spain

7. Liver Cancer Program Divisions of Liver Diseases and Hematology/Medical Oncology Department of Medicine Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY USA

8. Department of Pathology Humanitas Clinical and Research Center IRCCS Milan Italy

9. Department of Biomedical Sciences Humanitas University Milan Italy

10. Department for BioMedical Research University of Bern Switzerland

11. SIB Swiss Institute of Bioinformatics Lausanne Switzerland

Funder

Horizon 2020 Framework Programme

Krebsliga Beider Basel

Generalitat de Catalunya

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Samuel Waxman Cancer Research Foundation

Krebsliga Schweiz

U.S. Department of Defense

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

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