Organoid Technology: Current Standing and Future Perspectives

Author:

Shariati Laleh12ORCID,Esmaeili Yasaman3,Haghjooy Javanmard Shaghayegh1,Bidram Elham13ORCID,Amini Abbas45ORCID

Affiliation:

1. Department of Biomaterials, Nanotechnology and Tissue Engineering, School of Advanced Technologies in Medicine  Isfahan University of Medical Sciences, Isfahan, Iran

2. Applied Physiology Research Center, Isfahan Cardiovascular Research Institute  Isfahan University of Medical Sciences, Isfahan, Iran

3. Biosensor Research Center, School of Advanced Technologies in Medicine  Isfahan University of Medical Sciences, Isfahan, Iran

4. Department of Mechanical Engineering  Australian College of Kuwait, Mishref, Safat, Kuwait

5. Centre for Infrastructure Engineering  Western Sydney University, Penrith, New South Wales, Australia

Abstract

Abstract Organoids are powerful systems to facilitate the study of individuals' disorders and personalized treatments. This emerging technology has improved the chance of translatability of drugs for preclinical therapies and mimicking of the complexity of organs, proposing numerous approaches for human disease modeling, tissue engineering, drug development, diagnosis, and regenerative medicine. In this review, we outline the history of organoid technology and summarize its faithful applications, and then we discuss the challenges and limitations encountered by three-dimensional organoids. Finally, we propose that human organoids offer a basic mechanistic infrastructure for “human modeling” systems to prescribe personalized medicines.

Funder

Isfahan University of Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,Molecular Medicine

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