Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice

Author:

Han Song-iee1,Komatsu Yoko1,Murayama Akiko12,Steffensen Knut R.3,Nakagawa Yoshimi4,Nakajima Yuka1,Suzuki Michiko1,Oie Shohei1,Parini Paolo3,Vedin Lise-Lotte5,Kishimoto Hiroyuki2,Shimano Hitoshi246,Gustafsson Jan-Åke57,Yanagisawa Junn12

Affiliation:

1. Graduate School of Life and Environmental Sciences; University of Tsukuba; Tsukuba Ibaraki Japan

2. Center for Tsukuba Advanced Research Alliance (TARA), Graduate School of Comprehensive Human Sciences, University of Tsukuba; Tsukuba Ibaraki Japan

3. Division of Clinical Chemistry; Department of Laboratory Medicine; Karolinska Institutet, Karolinska University Hospital Huddinge; Stockholm Sweden

4. Department of Internal Medicine (Endocrinology and Metabolism); Faculty of Medicine; University of Tsukuba; Ibaraki Japan

5. Center for Biosciences; Department of Biosciences and Nutrition; Karolinska Institutet; Stockholm Sweden

6. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba; Ibaraki Japan

7. Center for Nuclear Receptors and Cell Signaling; Department of Biology and Biochemistry; University of Houston; Houston TX

Funder

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

Hepatology

Reference34 articles.

1. Fatty liver: a novel component of the metabolic syndrome;Kotronen;Arterioscler Thromb Vasc Biol,2007

2. Causes and metabolic consequences of fatty liver;Stefan;Endocr Rev,2008

3. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR;Calkin;Mol Cell Bio,2012

4. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities;Jakobsson;Trends Pharmacol Sci,2012

5. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver;Horton;J Clin Invest,2002

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