EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma-Reference-Cited by-同舟云学术

EEF1A2 inactivates p53 by way of PI3K/AKT/mTOR-dependent stabilization of MDM4 in hepatocellular carcinoma

Published:2014-03-27 Issue:5 Volume:59 Page:1886-1899
ISSN:0270-9139
Container-title:Hepatology
language:en
Short-container-title:Hepatology

Author:

Pellegrino Rossella¹,Calvisi Diego F.²,Neumann Olaf¹,Kolluru Venkatesh³,Wesely Josephine³,Chen Xin⁴,Wang Chunmei⁴,Wuestefeld Torsten⁵,Ladu Sara⁶,Elgohary Nahla¹,Bermejo Justo Lorenzo⁷,Radlwimmer Bernhard⁸,Zörnig Martin³,Zender Lars⁵,Dombrowski Frank²,Evert Matthias²,Schirmacher Peter¹,Longerich Thomas¹

Affiliation:

1. Institute of Pathology, University Hospital Heidelberg; Heidelberg Germany

2. Institute of Pathology, University of Greifswald; Greifswald Germany

3. Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy; Frankfurt/Main Germany

4. Department of Bioengineering and Therapeutic Sciences; University of California; San Francisco CA USA

5. Division of Translational Gastrointestinal Oncology; Department of Internal Medicine I; University of Tübingen; Tübingen Germany

6. Department of Medicine and Aging; University of Chieti; Chieti Italy

7. Institute of Medical Biometry and Informatics, University Hospital Heidelberg; Heidelberg Germany

8. Division of Molecular Genetics; German Cancer Research Center; Heidelberg Germany

Funder

Deutsche Forschungsgemeinschaft

National Institutes of Health

German Federal Ministry of Health (BMG)

LOEWE inititative Oncogenic Signaling Franfurt

Ministry of Higher Education, Research and the Arts of the state of Hessen (HMWK)

Siemens/DAAD Post Graduate Programme

Publisher

Wiley

Subject

Hepatology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/hep.26954/fullpdf

Reference33 articles.

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2. Twenty years of p53 research: structural and functional aspects of the p53 protein;May;Oncogene,1999

3. Low incidence of p53 mutations in European hepatocellular carcinomas with heterogeneous mutation as a rare event;Kubicka;J Hepatol,1995

4. Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma;Guichard;Nat Genet,2012

5. Molecular epidemiology of human cancer;Hussain;Recent Results Cancer Res,1998

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