Rho-kinase inhibitor Y-27632 downregulates LPS-induced IL-6 and IL-8 production via blocking p38 MAPK and NF-κB pathways in human gingival fibroblasts

Author:

Kang Wenyan12,Shang Lingling12,Wang Ting12,Liu Hongrui12,Ge Shaohua12

Affiliation:

1. Shandong Provincial Key Laboratory of Oral Tissue Regeneration; School of Stomatology, Shandong University; Shandong Jinan China

2. Department of Periodontology; School of Stomatology, Shandong University; Shandong Jinan China

Publisher

Wiley

Subject

Periodontics

Reference50 articles.

1. A polymicrobial disruption of host homeostasis;Darveau RP;Nat Rev Microbiol,2010

2. Periodontal disease: linking the primary inflammation to bone loss;Di Benedetto;Clin Dev Immunol,2013

3. The role of inflammatory mediators in the pathogenesis of periodontal disease;Page;J Periodontal Res,1991

4. Clinical and microbiologic effect of nonsurgical periodontal therapy on patients with chronic or aggressive periodontitis;Liu;Quintessence Int,2013

5. Determination of the antibacterial activity of simvastatin against periodontal pathogens, Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans: an in vitro study;Emani;Contemp Clin Dent,2014

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