Accumulation of Lewy‐Related Pathology Starts in Middle Age: The Tampere Sudden Death Study-Reference-Cited by-同舟云学术

Accumulation of Lewy‐Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Published:2024-03-19 Issue:5 Volume:95 Page:843-848
ISSN:0364-5134
Container-title:Annals of Neurology
language:en
Short-container-title:Annals of Neurology

Author:

Kok Eloise H¹²,Paetau Anders¹³,Martiskainen Mika²⁴,Lyytikäinen Leo‐Pekka²⁵,Lehtimäki Terho²⁵,Karhunen Pekka²⁵,Myllykangas Liisa¹³^ORCID

Affiliation:

1. Department of Pathology University of Helsinki Helsinki Finland

2. Department of Clinical Chemistry, Finnish Cardiovascular Research Center ‐ Tampere, Faculty of Medicine and Health Technology Tampere University Tampere Finland

3. Department of Pathology, HUS Diagnostic Center Helsinki University Hospital Helsinki Finland

4. Finnish Institute for Health and Welfare Government Services, Forensic Medicine Unit Helsinki Finland

5. Fimlab Laboratories Tampere Finland

Abstract

When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha‐synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy‐related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years‐of‐age non‐hospitalized population. ANN NEUROL 2024;95:843–848

Funder

Suomen Kulttuurirahasto

Seventh Framework Programme

Suomen Aivosäätiö

Maire Taposen Säätiö

Medicinska Understödsföreningen Liv och Hälsa

Tays

Helsingin ja Uudenmaan Sairaanhoitopiiri

Academy of Finland

Sydäntutkimussäätiö

Päivikki ja Sakari Sohlbergin Säätiö

Publisher