Long‐term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study

Author:

Kim Hyun1234ORCID,Ang Ting Fang Alvin25,Thomas Robert J.6,Lyons Michael J.1,Au Rhoda2378

Affiliation:

1. Department of Psychological & Brain Sciences Boston University Boston Massachusetts USA

2. Framingham Heart Study Boston University School of Medicine Boston Massachusetts USA

3. Department of Psychiatry Columbia University New York New York USA

4. Department of Geriatric Psychiatry New York State Psychiatric Institute New York New York USA

5. Department of Anatomy and Neurobiology Boston University School of Medicine Boston Massachusetts USA

6. Department of Medicine Division of Pulmonary Critical Care & Sleep Beth Israel Deaconess Medical Center, Harvard Medical School Boston Massachusetts USA

7. Department of Neurology Medicine and Alzheimer's Disease Research Center Boston University School of Medicine Boston Massachusetts USA

8. Department of Epidemiology Boston University School of Public Health Boston Massachusetts USA

Abstract

AbstractINTRODUCTIONLong‐term blood pressure (BP) measures, such as visit‐to‐visit BP variability (BPV) and cumulative BP, are strong indicators of cardiovascular risks. This study modeled up to 20 years of BP patterns representative of midlife by using BPV and cumulative BP, then examined their associations with development of dementia in later life.METHODSFor 3201 individuals from the Framingham Heart Study, multivariate logistic regression analyses were performed to examine the association between long‐term BP patterns during midlife and the development of dementia (ages ≥ 65).RESULTSAfter adjusting for covariates, every quartile increase in midlife cumulative BP was associated with a sequential increase in the risk of developing dementia (e.g., highest quartile of cumulative systolic blood pressure had approximately 2.5‐fold increased risk of all‐cause dementia). BPV was not significantly associated with dementia.DISCUSSIONFindings suggest that cumulative BP over the course of midlife predicts risk of dementia in later life.HIGHLIGHTSLong‐term blood pressure (BP) patterns are strong indicators of vascular risks.Cumulative BP and BP variability (BPV) were used to reflect BP patterns across midlife.High cumulative BP in midlife is associated with increased dementia risk.Visit‐to‐visit BPV was not associated with the onset of dementia.

Funder

National Institute on Aging

National Institute of Neurological Disorders and Stroke

Alzheimer's Association

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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