Endometrial cytological findings for a mesonephric‐like endometrial adenocarcinoma: A case report

Author:

Omine Hirotaka1,Ishida Kazuyuki12ORCID,Sasaki Natsuki1ORCID,Kato Hikaru1,Nagai Tamiko1,Ishikawa Mihoko1,Takaoka Mina2,Noda Shuhei2,Matsuda Hadzki2,Mitsuhashi Akira3

Affiliation:

1. Department of Pathology Dokkyo Medical University Hospital Mibu Japan

2. Department of Diagnostic Pathology Dokkyo Medical University Mibu Japan

3. Department of Obstetrics and Gynecology Dokkyo Medical University Mibu Japan

Abstract

AbstractA mesonephric‐like endometrial adenocarcinoma (ML‐EAC) is very rare and has a worse prognosis than other endometrial carcinomas. We describe an ML‐EAC and report our endometrial cytological findings. A 76‐year‐old woman presented with irregular genital bleeding and a uterine mass. Endometrial cytology revealed atypical cylindrical or spindle‐shaped cells in the form of small aggregates or solitary cells. The cell aggregates exhibited irregularly stacked papillary structures, small glandular structures, and fenestrated structures. The atypical cells had a nucleus with fine‐granular chromatin and a granular cytoplasm, and nuclear grooves and intranuclear pseudo‐inclusions were present. Hyaline globules were observed in the glandular lumens and in the background. The presumptive histological type was an adenocarcinoma, but the cytological features were different from those of an endometrioid carcinoma. A histological examination of the endometrial biopsy revealed an adenocarcinoma, and a simple hysterectomy was performed. A grayish‐white elevated mass measuring 90 mm × 70 mm × 40 mm was observed on the uterine corpus in the hysterectomy specimen. Histologically, the tumor proliferated as complex tubular structures containing eosinophilic colloid‐like materials and trabecular structures. The tumor cells were diffuse and positive for GATA‐3 and partially positive for thyroid transcription factor‐1. Estrogen and progesterone receptors were negative. An ML‐EAC was diagnosed. The tumor was invasive and extended beyond one‐half of the muscle layer with a high degree of vascular invasion. In conclusion, we need to focus on the various shapes of the cell aggregate, nuclear grooves, and intranuclear pseudo‐inclusions of tumor cells to distinguish an ML‐EAC from other endometrial carcinomas in endometrial cytology.

Publisher

Wiley

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3