Whole genome sequencing of melanomas in adolescent and young adults reveals distinct mutation landscapes and the potential role of germline variants in disease susceptibility

Author:

Wilmott James S.123ORCID,Johansson Peter A.4,Newell Felicity4,Waddell Nicola45,Ferguson Peter1236,Quek Camelia123,Patch Ann-Marie4,Nones Katia4,Shang Ping123,Pritchard Antonia L.47,Kazakoff Stephen45,Holmes Oliver45,Leonard Conrad45,Wood Scott45,Xu Qinying45,Saw Robyn P. M.126,Spillane Andrew J.128,Stretch Jonathan R.12,Shannon Kerwin F.1269,Kefford Richard F.110,Menzies Alexander M.128,Long Georgina V.1238,Thompson John F.126,Pearson John V.45,Mann Graham J.1211,Hayward Nicholas K.4,Scolyer Richard A.1236

Affiliation:

1. Melanoma Institute Australia; The University of Sydney; Sydney Australia

2. Sydney Medical School; The University of Sydney; Sydney Australia

3. Charles Perkins Centre; The University of Sydney; Sydney Australia

4. QIMR Berghofer Medical Research Institute; Brisbane Australia

5. Institute for Molecular Bioscience; University of Queensland; Brisbane Australia

6. Royal Prince Alfred Hospital; Camperdown Australia

7. The University of the Highlands and Islands; Inverness United Kingdom

8. Royal North Shore Hospital; New South Wales Australia

9. Chris O'Brien Lifehouse; Royal Prince Alfred Hospital; Camperdown Australia

10. Macquarie University; North Ryde Australia

11. Centre for Cancer Research, Westmead Institute for Medical Research; The University of Sydney; Westmead Australia

Funder

The Melanoma Foundation of the University of Sydney

Keith Boden

The University of Sydney Medical Foundation

Cancer Institute NSW

National Health and Medical Research Council

Australian Cancer Research Foundation and Cancer Institute NSW

National Health and Medical Research Council of Australia

New South Wales Department of Health

New South Wales State Government

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference50 articles.

1. Cancer epidemiology in older adolescents and young adults 15 to 29 years of age, including SEER incidence and survival: 1975-2000;Bleyer;National Cancer Institute, NIH Pub,2007

2. Cancer in adolescents and young adults in Australia;Welfare AIoHa;Cancer series Canberra: AIHW,2011

3. Pediatric and AYA invasive cutaneous melanoma: Population-based study comparing adult melanoma cases;Cinar;J Clin Oncol,2008

4. Melanoma in pediatric, adolescent, and young adult patients;Kirkwood;Semin Oncol,2009

5. National Cancer Institute Next Steps for A, Young Adult Oncology Epidemiology Working G. Comparison of cancer survival trends in the United States of adolescents and young adults with those in children and older adults;Keegan;Cancer,2016

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