Prodrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes

Author:

Altanerova Ursula1,Jakubechova Jana1,Benejova Katarina1,Priscakova Petra2,Pesta Martin345,Pitule Pavel4,Topolcan Ondrej5,Kausitz Juraj1,Zduriencikova Martina6,Repiska Vanda2,Altaner Cestmir16ORCID

Affiliation:

1. St. Elisabeth Cancer Institute; Stem Cell Preparation Department; Bratislava Slovakia

2. Faculty of Medicine, Institute of Medical Biology, Genetics and Clinical Genetics; University Hospital Bratislava, Comenius University in Bratislava; Bratislava Slovakia

3. Department of Biology, Faculty of Medicine in Pilsen; Charles University in Prague; Pilsen Czech Republic

4. Laboratory of tumor biology, Biomedical Center, Faculty of Medicine in Pilsen; Charles University; Prague Czech Republic

5. University Hospital in Pilsen; Department of Nuclear Medicine - Immunoanalytic Laboratory; Pilsen Czech Republic

6. Cancer Research Institute; Biomedical Center, Slovak Academy of Sciences; Bratislava Slovakia

Funder

The Ministry of Education Youth and Sports of the Czech Republic

The National Sustainability Program I

The Slovak League against Cancer

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference36 articles.

1. Tumour-associated mesenchymal stem/stromal cells: emerging therapeutic targets;Shi;Nat Rev Drug Discov,2017

2. Tumors: wound that do not heal. Similarities between tumor stroma generation and wound healing;Dvorak;N Engl J Med,1986

3. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases;Son;Stem Cells,2006

4. Bone marrow derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors;Studeny;Cancer Res,2002

5. Aboody K. 2015 https://www.clinicaltrials.gov/ct2/show/NCT01172964

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