Loss of neural crest-associated gene FOXD1 impairs melanoma invasion and migration via RAC1B downregulation

Author:

Wu Huizi123,Larribère Lionel12ORCID,Sun Qian12,Novak Daniel12,Sachindra Sachindra12,Granados Karol12,Umansky Viktor12,Utikal Jochen12ORCID

Affiliation:

1. Skin Cancer Unit; German Cancer Research Center (DKFZ); Heidelberg Germany

2. Department of Dermatology, Venereology and Allergology; University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg; Mannheim Germany

3. Department of Pharmacy, Xiangya Hospital; Central South University; Changsha China

Funder

The RTG 2099 (Hallmarks of skin cancer J.U, V.U).

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference30 articles.

1. The melanocyte lineage in development and disease;Mort;Development [Internet],2015

2. Why is melanoma so metastatic?;Braeuer;Pigment Cell Melanoma Res [Internet],2014

3. A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma;Caramel;Cancer Cell [Internet],2013

4. Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment;Kulesa;Proc Natl Acad Sci U S A [Internet],2006

5. Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells;Knappe;Stem Cells,2016

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