CircSMARCA5 functions as a potential biomarker for clinicopathology and therapy in solid tumors: A systematic review and meta‐analysis

Abstract

AbstractCircular RNAs (circRNAs) have been implicated in cancer proliferation, migration, and invasion. Among various circRNAs, circSMARAC5 attracted our great attention. The research aimed at broadening the knowledge on circSMARCA5 and exploring its function in clinicopathology and therapy in solid tumors. The incorporated research was explored via Web of Science, PubMed, Embase, and Cochrane Library, consisting of 1048 patients. This study was calculated using STATA 12.0 and Review Manager 5.3 software. Clinicopathological characteristics and therapeutic targets were analyzed using pooled odd ratios (ORs) with 95% confidence intervals (CIs). And the ceRNA network of circSMARCA5 was constructed via Cytoscape 3.9.0. Eventually, there were eight studies included in conducting clinicopathological characteristics and four literature used in exploring therapeutic targets. Patients with low expression of circSMARCA5 were closely associated with gender (OR = 1.367, 95% CI = 1.003–1.862, p = .048) and pathological differentiation (OR = 1.627, 95% CI = 1.130–2.343, p = .009). Among these modulating axes, the most commonly microRNA was miR‐432. In the near future, circSMARCA5 may be a promising diagnostic biomarker and a new therapeutic target.