Metabolism and disposition of the αv-integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans-Reference-Cited by-同舟云学术

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Metabolism and disposition of the αv-integrin ß3/ß5 receptor antagonist cilengitide, a cyclic polypeptide, in humans

Published:2015-03-23 Issue:7 Volume:55 Page:815-824
ISSN:0091-2700
Container-title:The Journal of Clinical Pharmacology
language:en
Short-container-title:The Journal of Clinical Pharmacology

Author:

Becker Andreas¹,von Richter Oliver¹,Kovar Andreas²,Scheible Holger³,van Lier Jan J.⁴,Johne Andreas¹

Affiliation:

1. Merck Serono-Global Early Development; Department of Clinical Pharmacology; Merck KGaA Darmstadt Germany

2. Sanofi Aventis; Frankfurt am Main Germany

3. Merck Serono-Global Early Development; Institute of Drug Metabolism and Pharmacokinetics; Merck KGaA Grafing Germany

4. Pharmaceutical Research Association (PRA); Zuidlaren The Netherlands

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference29 articles.

1. Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation;Mas-Moruno;Anticancer Agents Med Chem.,2010

2. Integrin ligands at a glance;Humphries;J Cell Sci.,2006

3. Integrins in cancer: biological implications and therapeutic opportunities;Desgrosellier;Nat Rev Cancer.,2010

4. Integrins as therapeutic targets;Goodman;Trends Pharmacol Sci.,2012

5. alpha v-Integrin antagonist EMD 121974 induces apoptosis in brain tumor cells growing on vitronectin and tenascin;Taga;Int J Cancer.,2002

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