Affiliation:
1. Department of Chemistry, School of Physical Sciences Doon University Dehradun India
2. Department of Chemistry Indian Institute of Technology Delhi New Delhi India
Abstract
Structural units substituted with imidazole motif play significant roles in many functional and biologically active molecules. Such units are important for naturally occurring chemicals, agrochemicals, medicines, and materials. An effective procedure employed for derivatizing imidazole is the arylation of CH bond with a high degree of regioselectively. C‐4 carbon in imidazole is the least preferred site of the CH arylation reaction. However, the C‐2 and C‐4 carbon centres are highly susceptible sites for arylation of imidazole. In recent years, palladium catalyzed direct coupling of imidazole and its derivatives with haloarenes has been developed. The present article aims to cover recent developments pertaining to the catalysis of CH functionalization of imidazoles by sulphur and/or selenium‐ligated palladium (II) complexes. Substrate scope of such reactions has been summarized. Variations in catalytic potential due to ligand binding mode, chalcogen donor, and other factors/features of the ligand are critically analyzed.
Funder
Science and Engineering Research Board
Subject
Inorganic Chemistry,General Chemistry
Cited by
7 articles.
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