Affiliation:
1. Infectious Diseases Division Hospital General Universitario de Elche Elche Spain
2. Centro de Investigación en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III Madrid Spain
3. Medical Oncology Department Gregorio Marañón University Hospital Madrid Spain
4. Department of Clinical Medicine Miguel Hernández University San Juan de Alicante Spain
Abstract
AbstractBackgroundCancer is the leading cause of mortality in people living with HIV (PWH) and is expected to account for a growing fraction of deaths as PWH age.MethodsIn this literature review, we have compiled the most recent developments in cancer screening and screening performance in PWH, which are currently primarily implemented in well‐resourced settings. This includes an assessment of the associated benefits, harms, and cost‐effectiveness. The article also addresses unmet needs and potential strategies for tailored screening in the HIV population.FindingsIncidence and mortality due to screenable cancer are higher in PWH than in the general population, and diagnosis is frequently made at younger ages and/or at more advanced stages, the latter amenable to improved screening. Adequate evidence on the benefits of screening is lacking for most cancers in the HIV population, in whom standard practice may be suboptimal. While cancer surveillance has helped reduce mortality in the general population, and interest in risk‐based strategies is growing, implementation of screening programs in the HIV care settings remains low.InterpretationGiven the devastating consequences of a late diagnosis, enhancing early detection of cancer is essential for improving patient outcomes. There is an urgent need to extend the investigation in cancer screening performance to PWH, evaluating whether personalized measures according to individual risk could result in higher efficiency and improve patient outcomes.
Funder
Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana
European Regional Development Fund
Instituto de Salud Carlos III
Subject
Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology
Cited by
2 articles.
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